| Player | Team | Opp | Att | Yds | Avg | Lg | TD | Result |
|---|---|---|---|---|---|---|---|---|
| James ConnerJ. Conner | PIT | @ CLE | 31 | 135 | 4.35 | 22t | 2 | T, 21-21 |
| Saquon BarkleyS. Barkley | NYG | vs. JAX | 18 | 106 | 5.89 | 68t | 1 | L, 20-15 |
| Isaiah CrowellI. Crowell | NYJ | @ DET | 10 | 102 | 10.20 | 62t | 2 | W, 48-17 |
| Todd GurleyT. Gurley | LA | @ OAK | 20 | 108 | 5.40 | 23 | 0 | W, 33-13 |
| Player | Team | Opp | Att | Yds | Avg | Lg | TD | Result |
|---|---|---|---|---|---|---|---|---|
| Tevin ColemanT. Coleman | ATL | vs. CAR | 16 | 107 | 6.69 | 36 | 0 | W, 31-24 |
| Matt BreidaM. Breida | SF | vs. DET | 11 | 138 | 12.55 | 66t | 1 | W, 30-27 |
| Phillip LindsayP. Lindsay | DEN | vs. OAK | 14 | 107 | 7.64 | 53 | 0 | W, 20-19 |
| Player | Team | Opp | Att | Yds | Avg | Lg | TD | Result |
|---|---|---|---|---|---|---|---|---|
| Christian McCaffreyC. McCaffrey | CAR | vs. CIN | 28 | 184 | 6.57 | 45 | 0 | W, 31-21 |
| Adrian PetersonA. Peterson | WAS | vs. GB | 19 | 120 | 6.32 | 41 | 2 | W, 31-17 |
| Todd GurleyT. Gurley (2) | LA | vs. LAC | 23 | 105 | 4.57 | 14 | 1 | W, 35-23 |
| Chris CarsonC. Carson | SEA | vs. DAL | 32 | 102 | 3.19 | 13 | 1 | W, 24-13 |
| Ezekiel ElliottE. Elliott | DAL | @ SEA | 16 | 127 | 7.94 | 26 | 0 | L, 24-13 |
| Kerryon JohnsonK. Johnson | DET | vs. NE | 16 | 101 | 6.31 | 15 | 0 | W, 26-10 |