| Player | Team | Opp | Att | Yds | Avg | Lg | TD | Result |
|---|---|---|---|---|---|---|---|---|
| Christian McCaffreyC. McCaffrey | CAR | vs. LA | 19 | 128 | 6.74 | 23 | 2 | L, 30-27 |
| Mark IngramM. Ingram | BAL | @ MIA | 14 | 107 | 7.64 | 49 | 2 | W, 59-10 |
| Dalvin CookD. Cook | MIN | vs. ATL | 21 | 111 | 5.29 | 22 | 2 | W, 28-12 |
| Marlon MackM. Mack | IND | @ LAC | 25 | 174 | 6.96 | 63t | 1 | L, 30-24 |
| Saquon BarkleyS. Barkley | NYG | @ DAL | 11 | 120 | 10.91 | 59 | 0 | L, 35-17 |
| Player | Team | Opp | Att | Yds | Avg | Lg | TD | Result |
|---|---|---|---|---|---|---|---|---|
| Lamar JacksonL. Jackson | BAL | vs. ARI | 16 | 120 | 7.50 | 19 | 0 | W, 23-17 |
| Matt BreidaM. Breida | SF | @ CIN | 12 | 121 | 10.08 | 34 | 0 | W, 41-17 |
| Dalvin CookD. Cook (2) | MIN | @ GB | 20 | 154 | 7.70 | 75t | 1 | L, 21-16 |
| Aaron JonesA. Jones | GB | vs. MIN | 23 | 116 | 5.04 | 15 | 1 | W, 21-16 |
| Saquon BarkleyS. Barkley (2) | NYG | vs. BUF | 18 | 107 | 5.94 | 27t | 1 | L, 28-14 |
| Ezekiel ElliottE. Elliott | DAL | @ WAS | 23 | 111 | 4.83 | 27 | 1 | W, 31-21 |
| Player | Team | Opp | Att | Yds | Avg | Lg | TD | Result |
|---|---|---|---|---|---|---|---|---|
| Ezekiel ElliottE. Elliott (2) | DAL | vs. MIA | 19 | 125 | 6.58 | 18 | 0 | W, 31-6 |
| Tony PollardT. Pollard | DAL | vs. MIA | 13 | 103 | 7.92 | 28 | 1 | W, 31-6 |
| Mark IngramM. Ingram (2) | BAL | @ KC | 16 | 103 | 6.44 | 21 | 3 | L, 33-28 |
| Dalvin CookD. Cook (3) | MIN | vs. OAK | 16 | 110 | 6.88 | 25 | 1 | W, 34-14 |
| Christian McCaffreyC. McCaffrey (2) | CAR | @ ARI | 24 | 153 | 6.38 | 76t | 1 | W, 38-20 |
| Player | Team | Opp | Att | Yds | Avg | Lg | TD | Result |
|---|---|---|---|---|---|---|---|---|
| Derrick HenryD. Henry | TEN | @ ATL | 27 | 100 | 3.70 | 16 | 0 | W, 24-10 |
| Nick ChubbN. Chubb | CLE | @ BAL | 20 | 165 | 8.25 | 88t | 3 | W, 40-25 |
| Frank GoreF. Gore | BUF | vs. NE | 17 | 109 | 6.41 | 41 | 0 | L, 16-10 |
| Kerryon JohnsonK. Johnson | DET | vs. KC | 26 | 125 | 4.81 | 14 | 0 | L, 34-30 |
| Chris CarsonC. Carson | SEA | @ ARI | 22 | 104 | 4.73 | 12 | 0 | W, 27-10 |
| Leonard FournetteL. Fournette | JAX | @ DEN | 29 | 225 | 7.76 | 81 | 0 | W, 26-24 |
| Player | Team | Opp | Att | Yds | Avg | Lg | TD | Result |
|---|---|---|---|---|---|---|---|---|
| Chris CarsonC. Carson (2) | SEA | vs. LA | 27 | 118 | 4.37 | 14 | 0 | W, 30-29 |
| Leonard FournetteL. Fournette (2) | JAX | @ CAR | 23 | 108 | 4.70 | 48 | 1 | L, 34-27 |
| Christian McCaffreyC. McCaffrey (3) | CAR | vs. JAX | 19 | 176 | 9.26 | 84t | 2 | W, 34-27 |
| Dalvin CookD. Cook (4) | MIN | @ NYG | 21 | 132 | 6.29 | 41 | 0 | W, 28-10 |
| Joshua JacobsJ. Jacobs | OAK | vs. CHI | 26 | 123 | 4.73 | 21 | 2 | W, 24-21 |
| Phillip LindsayP. Lindsay | DEN | @ LAC | 15 | 114 | 7.60 | 32 | 1 | W, 20-13 |
| Aaron JonesA. Jones (2) | GB | @ DAL | 19 | 107 | 5.63 | 18t | 4 | W, 34-24 |
| Marlon MackM. Mack (2) | IND | @ KC | 29 | 132 | 4.55 | 30 | 0 | W, 19-13 |
| Matt BreidaM. Breida (2) | SF | vs. CLE | 11 | 114 | 10.36 | 83t | 1 | W, 31-3 |
| Player | Team | Opp | Att | Yds | Avg | Lg | TD | Result |
|---|---|---|---|---|---|---|---|---|
| Lamar JacksonL. Jackson (2) | BAL | vs. CIN | 19 | 152 | 8.00 | 36 | 1 | W, 23-17 |
| Chris CarsonC. Carson (3) | SEA | @ CLE | 24 | 124 | 5.17 | 25 | 1 | W, 32-28 |
| Nick ChubbN. Chubb (2) | CLE | vs. SEA | 20 | 122 | 6.10 | 52 | 2 | L, 32-28 |
| Carlos HydeC. Hyde | HOU | @ KC | 26 | 116 | 4.46 | 26 | 1 | W, 31-24 |
| Adrian PetersonA. Peterson | WAS | @ MIA | 23 | 118 | 5.13 | 25 | 0 | W, 17-16 |
| Ezekiel ElliottE. Elliott (3) | DAL | @ NYJ | 28 | 105 | 3.75 | 13 | 1 | L, 24-22 |