| Player | Team | Gms | Att | Cmp | Pct | Yds | YPA | TD | TD%T% | Int | Int%I% | Lg | Sack | Loss | Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Ryan TannehillR. Tannehill | TEN | 12 | 286 | 201 | 70.3 | 2,742 | 9.6 | 22 | 7.7 | 6 | 2.1 | 91t | 31 | 212 | 117.5 |
| Drew BreesD. Brees | NO | 11 | 378 | 281 | 74.3 | 2,979 | 7.9 | 27 | 7.1 | 4 | 1.1 | 61t | 12 | 89 | 116.3 |
| Lamar JacksonL. Jackson | BAL | 15 | 401 | 265 | 66.1 | 3,127 | 7.8 | 36 | 9.0 | 6 | 1.5 | 83t | 23 | 106 | 113.3 |
| Kirk CousinsK. Cousins | MIN | 15 | 444 | 307 | 69.1 | 3,603 | 8.1 | 26 | 5.9 | 6 | 1.4 | 66 | 28 | 206 | 107.4 |
| Russell WilsonR. Wilson | SEA | 16 | 516 | 341 | 66.1 | 4,110 | 8.0 | 31 | 6.0 | 5 | 1.0 | 60t | 48 | 319 | 106.3 |
| Matthew StaffordM. Stafford | DET | 8 | 291 | 187 | 64.3 | 2,499 | 8.6 | 19 | 6.5 | 5 | 1.7 | 66 | 18 | 137 | 106.0 |
| Patrick MahomesP. Mahomes | KC | 14 | 484 | 319 | 65.9 | 4,031 | 8.3 | 26 | 5.4 | 5 | 1.0 | 83t | 17 | 127 | 105.3 |
| Jimmy GaroppoloJ. Garoppolo | SF | 16 | 476 | 329 | 69.1 | 3,978 | 8.4 | 27 | 5.7 | 13 | 2.7 | 75t | 36 | 237 | 102.0 |
| Derek CarrD. Carr | OAK | 16 | 513 | 361 | 70.4 | 4,054 | 7.9 | 21 | 4.1 | 8 | 1.6 | 75 | 29 | 184 | 100.8 |
| Dak PrescottD. Prescott | DAL | 16 | 596 | 388 | 65.1 | 4,902 | 8.2 | 30 | 5.0 | 11 | 1.9 | 62 | 23 | 151 | 99.7 |
| Deshaun WatsonD. Watson | HOU | 15 | 495 | 333 | 67.3 | 3,852 | 7.8 | 26 | 5.2 | 12 | 2.4 | 54 | 44 | 257 | 98.0 |
| Aaron RodgersA. Rodgers | GB | 16 | 569 | 353 | 62.0 | 4,002 | 7.0 | 26 | 4.6 | 4 | 0.7 | 74t | 36 | 284 | 95.4 |
| Carson WentzC. Wentz | PHI | 16 | 607 | 388 | 63.9 | 4,039 | 6.7 | 27 | 4.5 | 7 | 1.1 | 53t | 37 | 230 | 93.1 |
| Matt RyanM. Ryan | ATL | 15 | 616 | 408 | 66.2 | 4,466 | 7.2 | 26 | 4.2 | 14 | 2.3 | 93t | 48 | 316 | 92.1 |
| Case KeenumC. Keenum | WAS | 10 | 247 | 160 | 64.8 | 1,707 | 6.9 | 11 | 4.5 | 5 | 2.0 | 69t | 15 | 145 | 91.3 |
| Gardner MinshewG. Minshew | JAX | 14 | 470 | 285 | 60.6 | 3,271 | 7.0 | 21 | 4.5 | 6 | 1.3 | 70t | 33 | 184 | 91.2 |
| Philip RiversP. Rivers | LAC | 16 | 591 | 390 | 66.0 | 4,615 | 7.8 | 23 | 3.9 | 20 | 3.4 | 84t | 34 | 222 | 88.5 |
| Tom BradyT. Brady | NE | 16 | 613 | 373 | 60.9 | 4,057 | 6.6 | 24 | 3.9 | 8 | 1.3 | 59 | 27 | 185 | 88.0 |
| Jacoby BrissettJ. Brissett | IND | 15 | 447 | 272 | 60.9 | 2,942 | 6.6 | 18 | 4.0 | 6 | 1.3 | 50 | 27 | 159 | 88.0 |
| Daniel JonesD. Jones | NYG | 13 | 459 | 284 | 61.9 | 3,027 | 6.6 | 24 | 5.2 | 12 | 2.6 | 75t | 38 | 295 | 87.7 |
| Kyler MurrayK. Murray | ARI | 16 | 542 | 349 | 64.4 | 3,722 | 6.9 | 20 | 3.7 | 12 | 2.2 | 88t | 48 | 309 | 87.4 |
| Jared GoffJ. Goff | LA | 16 | 626 | 394 | 62.9 | 4,638 | 7.4 | 22 | 3.5 | 16 | 2.6 | 66 | 22 | 170 | 86.5 |
| Ryan FitzpatrickR. Fitzpatrick | MIA | 15 | 502 | 311 | 62.0 | 3,529 | 7.0 | 20 | 4.0 | 13 | 2.6 | 51 | 40 | 209 | 85.5 |
| Josh AllenJ. Allen | BUF | 16 | 461 | 271 | 58.8 | 3,089 | 6.7 | 20 | 4.3 | 9 | 1.9 | 53t | 38 | 237 | 85.3 |
| Joe FlaccoJ. Flacco | DEN | 8 | 262 | 171 | 65.3 | 1,822 | 7.0 | 6 | 2.3 | 5 | 1.9 | 70t | 26 | 194 | 85.1 |
| Sam DarnoldS. Darnold | NYJ | 13 | 441 | 273 | 61.9 | 3,024 | 6.9 | 19 | 4.3 | 13 | 3.0 | 92t | 33 | 212 | 84.3 |
| Jameis WinstonJ. Winston | TB | 16 | 626 | 380 | 60.7 | 5,109 | 8.2 | 33 | 5.3 | 30 | 4.8 | 71t | 47 | 282 | 84.3 |
| Mitchell TrubiskyM. Trubisky | CHI | 15 | 516 | 326 | 63.2 | 3,138 | 6.1 | 17 | 3.3 | 10 | 1.9 | 53 | 38 | 234 | 83.0 |
| Mason RudolphM. Rudolph | PIT | 10 | 283 | 176 | 62.2 | 1,765 | 6.2 | 13 | 4.6 | 9 | 3.2 | 76t | 15 | 124 | 82.0 |
| Kyle AllenK. Allen | CAR | 13 | 489 | 303 | 62.0 | 3,322 | 6.8 | 17 | 3.5 | 16 | 3.3 | 52t | 46 | 397 | 80.0 |
| Baker MayfieldB. Mayfield | CLE | 16 | 534 | 317 | 59.4 | 3,827 | 7.2 | 22 | 4.1 | 21 | 3.9 | 89t | 40 | 285 | 78.8 |
| Andy DaltonA. Dalton | CIN | 13 | 528 | 314 | 59.5 | 3,494 | 6.6 | 16 | 3.0 | 14 | 2.6 | 66t | 37 | 249 | 78.3 |