| Player | Team | Gms | Att | Cmp | Pct | Yds | YPA | TD | TD%T% | Int | Int%I% | Lg | Sack | Loss | Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Tom BradyT. Brady | NE | 16 | 578 | 398 | 68.9 | 4,806 | 8.3 | 50 | 8.7 | 8 | 1.4 | 69t | 21 | 128 | 117.2 |
| Ben RoethlisbergerB. Roethlisberger | PIT | 15 | 404 | 264 | 65.3 | 3,154 | 7.8 | 32 | 7.9 | 11 | 2.7 | 83 | 47 | 347 | 104.1 |
| David GarrardD. Garrard | JAX | 12 | 325 | 208 | 64.0 | 2,509 | 7.7 | 18 | 5.5 | 3 | 0.9 | 59t | 21 | 99 | 102.2 |
| Peyton ManningP. Manning | IND | 16 | 515 | 337 | 65.4 | 4,040 | 7.8 | 31 | 6.0 | 14 | 2.7 | 73t | 21 | 124 | 98.0 |
| Tony RomoT. Romo | DAL | 16 | 520 | 335 | 64.4 | 4,211 | 8.1 | 36 | 6.9 | 19 | 3.6 | 59t | 24 | 176 | 97.4 |
| Brett FavreB. Favre | GB | 16 | 535 | 356 | 66.5 | 4,155 | 7.8 | 28 | 5.2 | 15 | 2.8 | 82t | 15 | 93 | 95.7 |
| Jeff GarciaJ. Garcia | TB | 13 | 327 | 209 | 63.9 | 2,440 | 7.5 | 13 | 4.0 | 4 | 1.2 | 69t | 19 | 104 | 94.6 |
| Matt HasselbeckM. Hasselbeck | SEA | 16 | 562 | 352 | 62.6 | 3,966 | 7.1 | 28 | 5.0 | 12 | 2.1 | 65 | 33 | 204 | 91.4 |
| Donovan McNabbD. McNabb | PHI | 14 | 473 | 291 | 61.5 | 3,324 | 7.0 | 19 | 4.0 | 7 | 1.5 | 75t | 44 | 227 | 89.9 |
| Kurt WarnerK. Warner | ARI | 14 | 451 | 281 | 62.3 | 3,417 | 7.6 | 27 | 6.0 | 17 | 3.8 | 62 | 20 | 140 | 89.8 |
| Drew BreesD. Brees | NO | 16 | 652 | 440 | 67.5 | 4,423 | 6.8 | 28 | 4.3 | 18 | 2.8 | 58 | 16 | 109 | 89.4 |
| Jay CutlerJ. Cutler | DEN | 16 | 467 | 297 | 63.6 | 3,497 | 7.5 | 20 | 4.3 | 14 | 3.0 | 68t | 27 | 153 | 88.1 |
| Matt SchaubM. Schaub | HOU | 11 | 289 | 192 | 66.4 | 2,241 | 7.8 | 9 | 3.1 | 9 | 3.1 | 77t | 16 | 126 | 87.2 |
| Carson PalmerC. Palmer | CIN | 16 | 575 | 373 | 64.9 | 4,131 | 7.2 | 26 | 4.5 | 20 | 3.5 | 70t | 17 | 119 | 86.7 |
| Chad PenningtonC. Pennington | NYJ | 9 | 260 | 179 | 68.8 | 1,765 | 6.8 | 10 | 3.9 | 9 | 3.5 | 57t | 26 | 178 | 86.1 |
| Sage RosenfelsS. Rosenfels | HOU | 9 | 240 | 154 | 64.2 | 1,684 | 7.0 | 15 | 6.2 | 12 | 5.0 | 53t | 6 | 48 | 84.8 |
| Derek AndersonD. Anderson | CLE | 16 | 527 | 298 | 56.5 | 3,787 | 7.2 | 29 | 5.5 | 19 | 3.6 | 78t | 14 | 109 | 82.5 |
| Philip RiversP. Rivers | SD | 16 | 460 | 277 | 60.2 | 3,152 | 6.8 | 21 | 4.6 | 15 | 3.3 | 49t | 22 | 163 | 82.4 |
| Jon KitnaJ. Kitna | DET | 16 | 561 | 355 | 63.3 | 4,068 | 7.2 | 18 | 3.2 | 20 | 3.6 | 91t | 51 | 320 | 80.9 |
| Jason CampbellJ. Campbell | WAS | 13 | 417 | 250 | 60.0 | 2,700 | 6.5 | 12 | 2.9 | 11 | 2.6 | 54 | 21 | 110 | 77.6 |
| Joey HarringtonJ. Harrington | ATL | 12 | 348 | 215 | 61.8 | 2,215 | 6.4 | 7 | 2.0 | 8 | 2.3 | 69t | 32 | 192 | 77.2 |
| Damon HuardD. Huard | KC | 11 | 332 | 206 | 62.0 | 2,257 | 6.8 | 11 | 3.3 | 13 | 3.9 | 58 | 36 | 234 | 76.8 |
| Brian GrieseB. Griese | CHI | 7 | 262 | 161 | 61.5 | 1,803 | 6.9 | 10 | 3.8 | 12 | 4.6 | 81t | 15 | 114 | 75.6 |
| Kyle BollerK. Boller | BAL | 12 | 275 | 168 | 61.1 | 1,743 | 6.3 | 9 | 3.3 | 10 | 3.6 | 53 | 24 | 159 | 75.2 |
| Eli ManningE. Manning | NYG | 16 | 529 | 297 | 56.1 | 3,336 | 6.3 | 23 | 4.3 | 20 | 3.8 | 60t | 27 | 217 | 73.9 |
| Vince YoungV. Young | TEN | 15 | 382 | 238 | 62.3 | 2,546 | 6.7 | 9 | 2.4 | 17 | 4.5 | 73 | 25 | 157 | 71.1 |
| Cleo LemonC. Lemon | MIA | 9 | 309 | 173 | 56.0 | 1,773 | 5.7 | 6 | 1.9 | 6 | 1.9 | 64t | 25 | 166 | 71.0 |
| Tarvaris JacksonT. Jackson | MIN | 12 | 294 | 171 | 58.2 | 1,911 | 6.5 | 9 | 3.1 | 12 | 4.1 | 71 | 19 | 70 | 70.8 |
| Trent EdwardsT. Edwards | BUF | 10 | 269 | 151 | 56.1 | 1,630 | 6.1 | 7 | 2.6 | 8 | 3.0 | 70t | 12 | 105 | 70.4 |
| Marc BulgerM. Bulger | STL | 12 | 378 | 221 | 58.5 | 2,392 | 6.3 | 11 | 2.9 | 15 | 4.0 | 40 | 37 | 269 | 70.3 |
| Brodie CroyleB. Croyle | KC | 9 | 224 | 127 | 56.7 | 1,227 | 5.5 | 6 | 2.7 | 6 | 2.7 | 35 | 17 | 101 | 69.9 |
| Rex GrossmanR. Grossman | CHI | 8 | 225 | 122 | 54.2 | 1,411 | 6.3 | 4 | 1.8 | 7 | 3.1 | 59t | 25 | 198 | 66.4 |
| Kellen ClemensK. Clemens | NYJ | 10 | 250 | 130 | 52.0 | 1,529 | 6.1 | 5 | 2.0 | 10 | 4.0 | 56 | 27 | 138 | 60.9 |