| Player | Team | Gms | Att | Cmp | Pct | Yds | YPA | TD | TD%T% | Int | Int%I% | Lg | Sack | Loss | Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Peyton ManningP. Manning | IND | 16 | 497 | 336 | 67.6 | 4,557 | 9.2 | 49 | 9.9 | 10 | 2.0 | 80t | 13 | 101 | 121.1 |
| Daunte CulpepperD. Culpepper | MIN | 16 | 548 | 379 | 69.2 | 4,717 | 8.6 | 39 | 7.1 | 11 | 2.0 | 82t | 46 | 238 | 110.9 |
| Drew BreesD. Brees | SD | 15 | 400 | 262 | 65.5 | 3,159 | 7.9 | 27 | 6.8 | 7 | 1.8 | 79t | 18 | 131 | 104.8 |
| Donovan McNabbD. McNabb | PHI | 15 | 469 | 300 | 64.0 | 3,875 | 8.3 | 31 | 6.6 | 8 | 1.7 | 80 | 32 | 192 | 104.7 |
| Ben RoethlisbergerB. Roethlisberger | PIT | 14 | 295 | 196 | 66.4 | 2,621 | 8.9 | 17 | 5.8 | 11 | 3.7 | 58 | 30 | 213 | 98.1 |
| Brian GrieseB. Griese | TB | 11 | 336 | 233 | 69.3 | 2,632 | 7.8 | 20 | 6.0 | 12 | 3.6 | 68 | 26 | 169 | 97.5 |
| Trent GreenT. Green | KC | 16 | 556 | 369 | 66.4 | 4,591 | 8.3 | 27 | 4.9 | 17 | 3.1 | 70t | 32 | 227 | 95.2 |
| Marc BulgerM. Bulger | STL | 14 | 485 | 321 | 66.2 | 3,964 | 8.2 | 21 | 4.3 | 14 | 2.9 | 56 | 41 | 302 | 93.7 |
| Tom BradyT. Brady | NE | 16 | 474 | 288 | 60.8 | 3,692 | 7.8 | 28 | 5.9 | 14 | 3.0 | 50 | 26 | 162 | 92.6 |
| Brett FavreB. Favre | GB | 16 | 540 | 346 | 64.1 | 4,088 | 7.6 | 30 | 5.6 | 17 | 3.1 | 79t | 12 | 93 | 92.4 |
| Chad PenningtonC. Pennington | NYJ | 13 | 370 | 242 | 65.4 | 2,673 | 7.2 | 16 | 4.3 | 9 | 2.4 | 48 | 18 | 103 | 91.0 |
| Jake DelhommeJ. Delhomme | CAR | 16 | 533 | 310 | 58.2 | 3,886 | 7.3 | 29 | 5.4 | 15 | 2.8 | 63 | 33 | 246 | 87.3 |
| Billy VolekB. Volek | TEN | 10 | 357 | 218 | 61.1 | 2,486 | 7.0 | 18 | 5.0 | 10 | 2.8 | 48t | 30 | 216 | 87.1 |
| Kurt WarnerK. Warner | NYG | 10 | 277 | 174 | 62.8 | 2,054 | 7.4 | 6 | 2.2 | 4 | 1.4 | 62t | 39 | 196 | 86.5 |
| Jake PlummerJ. Plummer | DEN | 16 | 521 | 303 | 58.2 | 4,089 | 7.8 | 27 | 5.2 | 20 | 3.8 | 85t | 15 | 90 | 84.5 |
| David CarrD. Carr | HOU | 16 | 466 | 285 | 61.2 | 3,531 | 7.6 | 16 | 3.4 | 14 | 3.0 | 69 | 49 | 301 | 83.5 |
| Matt HasselbeckM. Hasselbeck | SEA | 14 | 474 | 279 | 58.9 | 3,382 | 7.1 | 22 | 4.6 | 15 | 3.2 | 60 | 30 | 155 | 83.1 |
| Byron LeftwichB. Leftwich | JAX | 14 | 441 | 267 | 60.5 | 2,941 | 6.7 | 15 | 3.4 | 10 | 2.3 | 65 | 25 | 114 | 82.2 |
| Aaron BrooksA. Brooks | NO | 16 | 542 | 309 | 57.0 | 3,810 | 7.0 | 21 | 3.9 | 16 | 3.0 | 57 | 41 | 223 | 79.5 |
| Tim RattayT. Rattay | SF | 9 | 325 | 198 | 60.9 | 2,169 | 6.7 | 10 | 3.1 | 10 | 3.1 | 65 | 37 | 211 | 78.1 |
| Michael VickM. Vick | ATL | 15 | 321 | 181 | 56.4 | 2,313 | 7.2 | 14 | 4.4 | 12 | 3.7 | 62 | 46 | 266 | 78.1 |
| Joey HarringtonJ. Harrington | DET | 16 | 489 | 274 | 56.0 | 3,047 | 6.2 | 19 | 3.9 | 12 | 2.5 | 62 | 36 | 196 | 77.5 |
| Carson PalmerC. Palmer | CIN | 13 | 432 | 263 | 60.9 | 2,897 | 6.7 | 18 | 4.2 | 18 | 4.2 | 76t | 25 | 178 | 77.3 |
| Jeff GarciaJ. Garcia | CLE | 11 | 252 | 144 | 57.1 | 1,731 | 6.9 | 10 | 4.0 | 9 | 3.6 | 99t | 24 | 99 | 76.7 |
| Drew BledsoeD. Bledsoe | BUF | 16 | 450 | 256 | 56.9 | 2,932 | 6.5 | 20 | 4.4 | 16 | 3.6 | 69t | 37 | 215 | 76.6 |
| Vinny TestaverdeV. Testaverde | DAL | 16 | 495 | 297 | 60.0 | 3,532 | 7.1 | 17 | 3.4 | 20 | 4.0 | 53 | 34 | 182 | 76.4 |
| Kerry CollinsK. Collins | OAK | 14 | 513 | 289 | 56.3 | 3,495 | 6.8 | 21 | 4.1 | 20 | 3.9 | 63 | 25 | 144 | 74.8 |
| Patrick RamseyP. Ramsey | WAS | 9 | 272 | 169 | 62.1 | 1,665 | 6.1 | 10 | 3.7 | 11 | 4.0 | 51 | 23 | 137 | 74.8 |
| Josh McCownJ. McCown | ARI | 14 | 408 | 233 | 57.1 | 2,511 | 6.2 | 11 | 2.7 | 10 | 2.5 | 48 | 31 | 263 | 74.1 |
| Kyle BollerK. Boller | BAL | 16 | 464 | 258 | 55.6 | 2,559 | 5.5 | 13 | 2.8 | 11 | 2.4 | 57t | 35 | 247 | 70.9 |
| Mark BrunellM. Brunell | WAS | 9 | 237 | 118 | 49.8 | 1,194 | 5.0 | 7 | 3.0 | 6 | 2.5 | 49 | 15 | 105 | 63.9 |
| Ken DorseyK. Dorsey | SF | 9 | 226 | 123 | 54.4 | 1,231 | 5.5 | 6 | 2.6 | 9 | 4.0 | 59 | 13 | 94 | 62.4 |
| A.J. FeeleyA. Feeley | MIA | 11 | 356 | 191 | 53.6 | 1,893 | 5.3 | 11 | 3.1 | 15 | 4.2 | 38 | 23 | 136 | 61.7 |