| Player | Team | Att | Cmp | Pct | Yds | YPA | TD | TD%T% | Int | Int%I% | Lg | Sack | Loss | Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Otto GrahamO. Graham | CLE | 285 | 161 | 56.5 | 2,785 | 9.8 | 19 | 6.7 | 10 | 3.5 | -- | -- | -- | 97.5 |
| Frankie AlbertF. Albert | SF | 260 | 129 | 49.6 | 1,862 | 7.2 | 27 | 10.4 | 16 | 6.2 | -- | -- | -- | 82.2 |
| George RattermanG. Ratterman | BUF | 252 | 146 | 57.9 | 1,777 | 7.0 | 14 | 5.6 | 13 | 5.2 | -- | -- | -- | 76.8 |
| Y.A. TittleY. Tittle | BAL | 289 | 148 | 51.2 | 2,209 | 7.6 | 14 | 4.8 | 18 | 6.2 | -- | -- | -- | 66.8 |