2010 Tennessee Titans Schedule & Results
| Regular Season |
| 09/12/2010 | Oakland Raiders | W, 38-13 | 1-0-0 | 69,143 |
| 09/19/2010 | Pittsburgh Steelers | L, 19-11 | 1-1-0 | 69,143 |
| 09/26/2010 | @ New York Giants | W, 29-10 | 2-1-0 | 78,386 |
| 10/03/2010 | Denver Broncos | L, 26-20 | 2-2-0 | 69,143 |
| 10/10/2010 | @ Dallas Cowboys | W, 34-27 | 3-2-0 | 90,616 |
| 10/18/2010 (Mon.) | @ Jacksonville Jaguars | W, 30-3 | 4-2-0 | 63,625 |
| 10/24/2010 | Philadelphia Eagles | W, 37-19 | 5-2-0 | 69,143 |
| 10/31/2010 | @ San Diego Chargers | L, 33-25 | 5-3-0 | 59,260 |
| 11/14/2010 | @ Miami Dolphins | L, 29-17 | 5-4-0 | 65,585 |
| 11/21/2010 | Washington Redskins | L, 19-16 OT | 5-5-0 | 69,143 |
| 11/28/2010 | @ Houston Texans | L, 20-0 | 5-6-0 | 70,855 |
| 12/05/2010 | Jacksonville Jaguars | L, 17-6 | 5-7-0 | 69,143 |
| 12/09/2010 (Thur.) | Indianapolis Colts | L, 30-28 | 5-8-0 | 69,143 |
| 12/19/2010 | Houston Texans | W, 31-17 | 6-8-0 | 69,143 |
| 12/26/2010 | @ Kansas City Chiefs | L, 34-14 | 6-9-0 | 65,606 |
| 01/02/2011 | @ Indianapolis Colts | L, 23-20 | 6-10-0 | 67,188 |
