2000 Tennessee Titans Schedule & Results
| Regular Season |
| 09/03/2000 | @ Buffalo Bills | L, 16-13 | 0-1-0 | 72,492 |
| 09/10/2000 | Kansas City Chiefs | W, 17-14 OT | 1-1-0 | 68,203 |
| 09/24/2000 | @ Pittsburgh Steelers | W, 23-20 | 2-1-0 | 51,769 |
| 10/01/2000 | New York Giants | W, 28-14 | 3-1-0 | 68,341 |
| 10/08/2000 | @ Cincinnati Bengals | W, 23-14 | 4-1-0 | 63,406 |
| 10/16/2000 (Mon.) | Jacksonville Jaguars | W, 27-13 | 5-1-0 | 68,498 |
| 10/22/2000 | @ Baltimore Ravens | W, 14-6 | 6-1-0 | 69,200 |
| 10/30/2000 (Mon.) | @ Washington Redskins | W, 27-21 | 7-1-0 | 83,472 |
| 11/05/2000 | Pittsburgh Steelers | W, 9-7 | 8-1-0 | 68,498 |
| 11/12/2000 | Baltimore Ravens | L, 24-23 | 8-2-0 | 68,490 |
| 11/19/2000 | Cleveland Browns | W, 24-10 | 9-2-0 | 68,498 |
| 11/26/2000 | @ Jacksonville Jaguars | L, 16-13 | 9-3-0 | 65,454 |
| 12/03/2000 | @ Philadelphia Eagles | W, 15-13 | 10-3-0 | 65,639 |
| 12/10/2000 | Cincinnati Bengals | W, 35-3 | 11-3-0 | 68,498 |
| 12/17/2000 | @ Cleveland Browns | W, 24-0 | 12-3-0 | 72,318 |
| 12/25/2000 (Mon.) | Dallas Cowboys | W, 31-0 | 13-3-0 | 68,498 |
