San Diego Chargers Schedule & Results
| Preseason | ||||
| Date | Opponent | Result | Record | Attendance |
| 08/14/2010 (Sat.) | Chicago Bears | W, 25-10 | 1-0-0 | 55,837 |
| 08/21/2010 (Sat.) | Dallas Cowboys | L, 16-14 | 1-1-0 | 64,372 |
| 08/27/2010 (Fri.) | @ New Orleans Saints | L, 36-21 | 1-2-0 | 70,031 |
| 09/02/2010 (Thur.) | @ San Francisco 49ers | -- | -- | -- |
| Regular Season | ||||
| Date | Opponent | Result | Record | Attendance |
| 09/13/2010 (Mon.) | @ Kansas City Chiefs | -- | -- | -- |
| 09/19/2010 | Jacksonville Jaguars | -- | -- | -- |
| 09/26/2010 | @ Seattle Seahawks | -- | -- | -- |
| 10/03/2010 | Arizona Cardinals | -- | -- | -- |
| 10/10/2010 | @ Oakland Raiders | -- | -- | -- |
| 10/17/2010 | @ St. Louis Rams | -- | -- | -- |
| 10/24/2010 | New England Patriots | -- | -- | -- |
| 10/31/2010 | Tennessee Titans | -- | -- | -- |
| 11/07/2010 | @ Houston Texans | -- | -- | -- |
| 11/22/2010 (Mon.) | Denver Broncos | -- | -- | -- |
| 11/28/2010 | @ Indianapolis Colts | -- | -- | -- |
| 12/05/2010 | Oakland Raiders | -- | -- | -- |
| 12/12/2010 | Kansas City Chiefs | -- | -- | -- |
| 12/16/2010 (Thur.) | San Francisco 49ers | -- | -- | -- |
| 12/26/2010 | @ Cincinnati Bengals | -- | -- | -- |
| 01/02/2011 | @ Denver Broncos | -- | -- | -- |