1988 Indianapolis Colts Schedule & Results
| Regular Season |
| 09/04/1988 | Houston Oilers | L, 17-14 OT | 0-1-0 | -- |
| 09/11/1988 | Chicago Bears | L, 17-13 | 0-2-0 | -- |
| 09/19/1988 (Mon.) | @ Cleveland Browns | L, 23-17 | 0-3-0 | -- |
| 09/25/1988 | Miami Dolphins | W, 15-13 | 1-3-0 | -- |
| 10/02/1988 | @ New England Patriots | L, 21-17 | 1-4-0 | -- |
| 10/09/1988 | @ Buffalo Bills | L, 34-23 | 1-5-0 | -- |
| 10/16/1988 | Tampa Bay Buccaneers | W, 35-31 | 2-5-0 | -- |
| 10/23/1988 | @ San Diego Chargers | W, 16-0 | 3-5-0 | -- |
| 10/31/1988 (Mon.) | Denver Broncos | W, 55-23 | 4-5-0 | -- |
| 11/06/1988 | New York Jets | W, 38-14 | 5-5-0 | -- |
| 11/13/1988 | @ Green Bay Packers | W, 20-13 | 6-5-0 | -- |
| 11/20/1988 | @ Minnesota Vikings | L, 12-3 | 6-6-0 | -- |
| 11/27/1988 | New England Patriots | W, 24-21 | 7-6-0 | -- |
| 12/04/1988 | @ Miami Dolphins | W, 31-28 | 8-6-0 | -- |
| 12/10/1988 (Sat.) | @ New York Jets | L, 34-16 | 8-7-0 | -- |
| 12/18/1988 | Buffalo Bills | W, 17-14 | 9-7-0 | -- |
