2008 Houston Texans Schedule & Results
| Regular Season |
| 09/07/2008 | @ Pittsburgh Steelers | L, 38-17 | 0-1-0 | 64,001 |
| 09/21/2008 | @ Tennessee Titans | L, 31-12 | 0-2-0 | 69,143 |
| 09/28/2008 | @ Jacksonville Jaguars | L, 30-27 OT | 0-3-0 | 64,061 |
| 10/05/2008 | Indianapolis Colts | L, 31-27 | 0-4-0 | 70,118 |
| 10/12/2008 | Miami Dolphins | W, 29-28 | 1-4-0 | 70,023 |
| 10/19/2008 | Detroit Lions | W, 28-21 | 2-4-0 | 70,081 |
| 10/26/2008 | Cincinnati Bengals | W, 35-6 | 3-4-0 | 70,112 |
| 11/02/2008 | @ Minnesota Vikings | L, 28-21 | 3-5-0 | 62,839 |
| 11/09/2008 | Baltimore Ravens | L, 41-13 | 3-6-0 | 70,552 |
| 11/16/2008 | @ Indianapolis Colts | L, 33-27 | 3-7-0 | 66,201 |
| 11/23/2008 | @ Cleveland Browns | W, 16-6 | 4-7-0 | 72,077 |
| 12/01/2008 (Mon.) | Jacksonville Jaguars | W, 30-17 | 5-7-0 | 70,809 |
| 12/07/2008 | @ Green Bay Packers | W, 24-21 | 6-7-0 | 70,245 |
| 12/14/2008 | Tennessee Titans | W, 13-12 | 7-7-0 | 70,831 |
| 12/21/2008 | @ Oakland Raiders | L, 27-16 | 7-8-0 | 43,687 |
| 12/28/2008 | Chicago Bears | W, 31-24 | 8-8-0 | 70,838 |
