1981 Baltimore Colts Schedule & Results
| Regular Season |
| 09/06/1981 | @ New England Patriots | W, 29-28 | 1-0-0 | -- |
| 09/13/1981 | Buffalo Bills | L, 35-3 | 1-1-0 | -- |
| 09/20/1981 | @ Denver Broncos | L, 28-10 | 1-2-0 | -- |
| 09/27/1981 | Miami Dolphins | L, 31-28 | 1-3-0 | -- |
| 10/04/1981 | @ Buffalo Bills | L, 23-17 | 1-4-0 | -- |
| 10/11/1981 | Cincinnati Bengals | L, 41-19 | 1-5-0 | -- |
| 10/18/1981 | San Diego Chargers | L, 43-14 | 1-6-0 | -- |
| 10/25/1981 | @ Cleveland Browns | L, 42-28 | 1-7-0 | -- |
| 11/01/1981 | @ Miami Dolphins | L, 27-10 | 1-8-0 | -- |
| 11/08/1981 | New York Jets | L, 41-14 | 1-9-0 | -- |
| 11/15/1981 | @ Philadelphia Eagles | L, 38-13 | 1-10-0 | -- |
| 11/22/1981 | St. Louis Cardinals | L, 35-24 | 1-11-0 | -- |
| 11/29/1981 | @ New York Jets | L, 25-0 | 1-12-0 | -- |
| 12/06/1981 | Dallas Cowboys | L, 37-13 | 1-13-0 | -- |
| 12/13/1981 | @ Washington Redskins | L, 38-14 | 1-14-0 | -- |
| 12/20/1981 | New England Patriots | W, 23-21 | 2-14-0 | -- |
