| Player | Team | Att | Cmp | Pct | Yds | Avg | TD | TD% | Int | Int% | Lg | Sack | Loss | Rate |
| Aaron Rodgers | GB | 552 | 371 | 67.2 | 4295 | 7.78 | 39 | 7.1 | 8 | 1.4 | 73 | 51 | 293 | 108.0 |
| Peyton Manning | Den | 583 | 400 | 68.6 | 4659 | 7.99 | 37 | 6.3 | 11 | 1.9 | 71t | 21 | 137 | 105.8 |
| Robert Griffin III | Was | 393 | 258 | 65.6 | 3200 | 8.14 | 20 | 5.1 | 5 | 1.3 | 88t | 30 | 217 | 102.4 |
| Russell Wilson | Sea | 393 | 252 | 64.1 | 3118 | 7.93 | 26 | 6.6 | 10 | 2.5 | 67 | 33 | 203 | 100.0 |
| Matt Ryan | Atl | 615 | 422 | 68.6 | 4719 | 7.67 | 32 | 5.2 | 14 | 2.3 | 80t | 28 | 210 | 99.1 |
| Tom Brady | NE | 637 | 401 | 63.0 | 4827 | 7.58 | 34 | 5.3 | 8 | 1.3 | 83t | 27 | 182 | 98.7 |
| Ben Roethlisberger | Pit | 449 | 284 | 63.3 | 3265 | 7.27 | 26 | 5.8 | 8 | 1.8 | 82t | 30 | 182 | 97.0 |
| Drew Brees | NO | 670 | 422 | 63.0 | 5177 | 7.73 | 43 | 6.4 | 19 | 2.8 | 80t | 26 | 190 | 96.3 |
| Matt Schaub | Hou | 544 | 350 | 64.3 | 4008 | 7.37 | 22 | 4.0 | 12 | 2.2 | 60t | 27 | 216 | 90.7 |
| Tony Romo | Dal | 648 | 425 | 65.6 | 4903 | 7.57 | 28 | 4.3 | 19 | 2.9 | 85t | 36 | 263 | 90.5 |
| Philip Rivers | SD | 527 | 338 | 64.1 | 3606 | 6.84 | 26 | 4.9 | 15 | 2.8 | 80t | 49 | 311 | 88.6 |
| Joe Flacco | Bal | 531 | 317 | 59.7 | 3817 | 7.19 | 22 | 4.1 | 10 | 1.9 | 61t | 35 | 227 | 87.7 |
| Andy Dalton | Cin | 528 | 329 | 62.3 | 3669 | 6.95 | 27 | 5.1 | 16 | 3.0 | 59t | 46 | 229 | 87.4 |
| Eli Manning | NYG | 536 | 321 | 59.9 | 3948 | 7.37 | 26 | 4.9 | 15 | 2.8 | 80t | 19 | 136 | 87.2 |
| Cam Newton | Car | 485 | 280 | 57.7 | 3869 | 7.98 | 19 | 3.9 | 12 | 2.5 | 82 | 36 | 244 | 86.2 |
| Carson Palmer | Oak | 565 | 345 | 61.1 | 4018 | 7.11 | 22 | 3.9 | 14 | 2.5 | 64t | 26 | 199 | 85.3 |
| Ryan Fitzpatrick | Buf | 505 | 306 | 60.6 | 3400 | 6.73 | 24 | 4.8 | 16 | 3.2 | 68t | 30 | 161 | 83.3 |
| Sam Bradford | Stl | 551 | 328 | 59.5 | 3702 | 6.72 | 21 | 3.8 | 13 | 2.4 | 80t | 35 | 233 | 82.6 |
| Josh Freeman | TB | 558 | 306 | 54.8 | 4065 | 7.28 | 27 | 4.8 | 17 | 3.0 | 95 | 26 | 161 | 81.6 |
| Jay Cutler | Chi | 434 | 255 | 58.8 | 3033 | 6.99 | 19 | 4.4 | 14 | 3.2 | 60t | 38 | 250 | 81.3 |
| Christian Ponder | Min | 483 | 300 | 62.1 | 2935 | 6.08 | 18 | 3.7 | 12 | 2.5 | 65 | 32 | 184 | 81.2 |
| Matthew Stafford | Det | 727 | 435 | 59.8 | 4967 | 6.83 | 20 | 2.8 | 17 | 2.3 | 57 | 29 | 212 | 79.8 |
| Nick Foles | Phi | 265 | 161 | 60.8 | 1699 | 6.41 | 6 | 2.3 | 5 | 1.9 | 46 | 20 | 131 | 79.1 |
| Michael Vick | Phi | 351 | 204 | 58.1 | 2362 | 6.73 | 12 | 3.4 | 10 | 2.8 | 77t | 28 | 153 | 78.1 |
| Blaine Gabbert | Jac | 278 | 162 | 58.3 | 1662 | 5.98 | 9 | 3.2 | 6 | 2.2 | 80t | 22 | 158 | 77.4 |
| Andrew Luck | Ind | 627 | 339 | 54.1 | 4374 | 6.98 | 23 | 3.7 | 18 | 2.9 | 70t | 41 | 246 | 76.5 |
| Ryan Tannehill | Mia | 484 | 282 | 58.3 | 3294 | 6.81 | 12 | 2.5 | 13 | 2.7 | 80t | 35 | 234 | 76.1 |
| Jake Locker | Ten | 314 | 177 | 56.4 | 2176 | 6.93 | 10 | 3.2 | 11 | 3.5 | 71t | 25 | 151 | 74.0 |
| Brandon Weeden | Cle | 517 | 297 | 57.4 | 3385 | 6.55 | 14 | 2.7 | 17 | 3.3 | 71t | 28 | 186 | 72.6 |
| Chad Henne | Jac | 308 | 166 | 53.9 | 2084 | 6.77 | 11 | 3.6 | 11 | 3.6 | 81t | 28 | 169 | 72.2 |
| Mark Sanchez | NYJ | 453 | 246 | 54.3 | 2883 | 6.36 | 13 | 2.9 | 18 | 4.0 | 66 | 34 | 209 | 66.9 |
| Matt Cassel | KC | 277 | 161 | 58.1 | 1796 | 6.48 | 6 | 2.2 | 12 | 4.3 | 46 | 19 | 101 | 66.7 |
| Player | Team | Att | Cmp | Pct | Yds | Avg | TD | TD% | Int | Int% | Lg | Sack | Loss | Rate |
| Johnny Hekker | Stl | 3 | 3 | 100.0 | 42 | 14.00 | 1 | 33.3 | 0 | 0.0 | 21 | 0 | 0 | 158.3 |
| Mohamed Sanu | Cin | 1 | 1 | 100.0 | 73 | 73.00 | 1 | 100.0 | 0 | 0.0 | 73t | 0 | 0 | 158.3 |
| Golden Tate | Sea | 1 | 1 | 100.0 | 23 | 23.00 | 1 | 100.0 | 0 | 0.0 | 23t | 0 | 0 | 158.3 |
| Shaun Hill | Det | 13 | 10 | 76.9 | 172 | 13.23 | 2 | 15.4 | 0 | 0.0 | 46t | 0 | 0 | 157.9 |
| Kyle Orton | Dal | 10 | 9 | 90.0 | 89 | 8.90 | 1 | 10.0 | 0 | 0.0 | 21 | 0 | 0 | 137.1 |
| Tim Masthay | GB | 2 | 1 | 50.0 | 27 | 13.50 | 1 | 50.0 | 0 | 0.0 | 27t | 0 | 0 | 135.4 |
| Derek Anderson | Car | 4 | 4 | 100.0 | 58 | 14.50 | 0 | 0.0 | 0 | 0.0 | 23 | 0 | 0 | 118.8 |
| Jeremy Kerley | NYJ | 1 | 1 | 100.0 | 42 | 42.00 | 0 | 0.0 | 0 | 0.0 | 42 | 0 | 0 | 118.8 |
| Mike Williams | TB | 1 | 1 | 100.0 | 28 | 28.00 | 0 | 0.0 | 0 | 0.0 | 28 | 0 | 0 | 118.8 |
| Chase Daniel | NO | 1 | 1 | 100.0 | 10 | 10.00 | 0 | 0.0 | 0 | 0.0 | 10 | 0 | 0 | 108.3 |
| Alex Smith | SF | 218 | 153 | 70.2 | 1737 | 7.97 | 13 | 6.0 | 5 | 2.3 | 55 | 24 | 137 | 104.1 |
| Kirk Cousins | Was | 48 | 33 | 68.8 | 466 | 9.71 | 4 | 8.3 | 3 | 6.2 | 77t | 3 | 27 | 101.6 |
| Colin Kaepernick | SF | 218 | 136 | 62.4 | 1814 | 8.32 | 10 | 4.6 | 3 | 1.4 | 57 | 16 | 112 | 98.3 |
| Matt Moore | Mia | 19 | 11 | 57.9 | 131 | 6.89 | 1 | 5.3 | 0 | 0.0 | 37 | 2 | 9 | 96.6 |
| Trent Edwards | Phi | 2 | 2 | 100.0 | 14 | 7.00 | 0 | 0.0 | 0 | 0.0 | 8 | 0 | 0 | 95.8 |
| Sidney Rice | Sea | 2 | 1 | 50.0 | 25 | 12.50 | 0 | 0.0 | 0 | 0.0 | 25 | 0 | 0 | 95.8 |
| Kevin Kolb | Ari | 183 | 109 | 59.6 | 1169 | 6.39 | 8 | 4.4 | 3 | 1.6 | 46t | 27 | 159 | 86.1 |
| Colt McCoy | Cle | 17 | 9 | 52.9 | 79 | 4.65 | 1 | 5.9 | 0 | 0.0 | 21 | 4 | 25 | 85.2 |
| Tim Tebow | NYJ | 8 | 6 | 75.0 | 39 | 4.88 | 0 | 0.0 | 0 | 0.0 | 23 | 2 | 7 | 84.9 |
| David Carr | NYG | 3 | 2 | 66.7 | 19 | 6.33 | 0 | 0.0 | 0 | 0.0 | 15 | 1 | 6 | 84.0 |
| Shane Lechler | Oak | 1 | 1 | 100.0 | 4 | 4.00 | 0 | 0.0 | 0 | 0.0 | 4 | 0 | 0 | 83.3 |
| Thaddeus Lewis | Cle | 32 | 22 | 68.8 | 204 | 6.38 | 1 | 3.1 | 1 | 3.1 | 23 | 3 | 14 | 83.3 |
| Matt Hasselbeck | Ten | 221 | 138 | 62.4 | 1367 | 6.19 | 7 | 3.2 | 5 | 2.3 | 37 | 14 | 103 | 81.0 |
| Rusty Smith | Ten | 5 | 3 | 60.0 | 34 | 6.80 | 0 | 0.0 | 0 | 0.0 | 17 | 0 | 0 | 80.4 |
| Dan Orlovsky | TB | 7 | 4 | 57.1 | 51 | 7.29 | 0 | 0.0 | 0 | 0.0 | 24 | 0 | 0 | 80.1 |
| Matt Flynn | Sea | 9 | 5 | 55.6 | 68 | 7.56 | 0 | 0.0 | 0 | 0.0 | 27 | 0 | 0 | 79.9 |
| Greg McElroy | NYJ | 31 | 19 | 61.3 | 214 | 6.90 | 1 | 3.2 | 1 | 3.2 | 30 | 11 | 71 | 79.2 |
| Tyler Thigpen | Buf | 5 | 3 | 60.0 | 30 | 6.00 | 0 | 0.0 | 0 | 0.0 | 12 | 0 | 0 | 77.1 |
| Jason Campbell | Chi | 51 | 32 | 62.7 | 265 | 5.20 | 2 | 3.9 | 2 | 3.9 | 45 | 6 | 49 | 72.8 |
| Terrelle Pryor | Oak | 30 | 14 | 46.7 | 155 | 5.17 | 2 | 6.7 | 1 | 3.3 | 38 | 0 | 0 | 70.8 |
| Brian Hoyer | Ari | 53 | 30 | 56.6 | 330 | 6.23 | 1 | 1.9 | 2 | 3.8 | 53 | 4 | 30 | 65.8 |
| Charlie Batch | Pit | 70 | 45 | 64.3 | 475 | 6.79 | 1 | 1.4 | 4 | 5.7 | 43 | 3 | 12 | 64.9 |
| Bruce Gradkowski | Cin | 11 | 5 | 45.5 | 65 | 5.91 | 0 | 0.0 | 0 | 0.0 | 44 | 0 | 0 | 64.6 |
| Graham Harrell | GB | 4 | 2 | 50.0 | 20 | 5.00 | 0 | 0.0 | 0 | 0.0 | 11 | 0 | 0 | 64.6 |
| Tyrod Taylor | Bal | 29 | 17 | 58.6 | 179 | 6.17 | 0 | 0.0 | 1 | 3.4 | 25 | 3 | 30 | 62.3 |
| Brady Quinn | KC | 197 | 112 | 56.9 | 1141 | 5.79 | 2 | 1.0 | 8 | 4.1 | 57 | 21 | 123 | 60.1 |
| Brock Osweiler | Den | 4 | 2 | 50.0 | 12 | 3.00 | 0 | 0.0 | 0 | 0.0 | 7 | 0 | 0 | 56.2 |
| John Skelton | Ari | 201 | 109 | 54.2 | 1132 | 5.63 | 2 | 1.0 | 9 | 4.5 | 40 | 15 | 98 | 55.4 |
| Byron Leftwich | Pit | 53 | 25 | 47.2 | 272 | 5.13 | 0 | 0.0 | 1 | 1.9 | 37 | 3 | 24 | 54.9 |
| Ryan Lindley | Ari | 171 | 89 | 52.0 | 752 | 4.40 | 0 | 0.0 | 7 | 4.1 | 28 | 12 | 91 | 46.7 |
| Matt Leinart | Oak | 33 | 16 | 48.5 | 115 | 3.48 | 0 | 0.0 | 1 | 3.0 | 20 | 1 | 9 | 44.4 |
| Kellen Clemens | Stl | 3 | 1 | 33.3 | 39 | 13.00 | 0 | 0.0 | 1 | 33.3 | 39 | 0 | 0 | 42.4 |
| Danario Alexander | SD | 1 | 0 | 0.0 | 0 | 0.00 | 0 | 0.0 | 0 | 0.0 | 0 | 0 | 0 | 39.6 |
| Armanti Edwards | Car | 1 | 0 | 0.0 | 0 | 0.00 | 0 | 0.0 | 0 | 0.0 | 0 | 0 | 0 | 39.6 |
| Brandon Fields | Mia | 1 | 0 | 0.0 | 0 | 0.00 | 0 | 0.0 | 0 | 0.0 | 0 | 0 | 0 | 39.6 |
| Peyton Hillis | KC | 1 | 0 | 0.0 | 0 | 0.00 | 0 | 0.0 | 0 | 0.0 | 0 | 0 | 0 | 39.6 |
| T.Y. Hilton | Ind | 1 | 0 | 0.0 | 0 | 0.00 | 0 | 0.0 | 0 | 0.0 | 0 | 0 | 0 | 39.6 |
| Josh Morgan | Was | 1 | 0 | 0.0 | 0 | 0.00 | 0 | 0.0 | 0 | 0.0 | 0 | 0 | 0 | 39.6 |
| Matt Prater | Den | 1 | 0 | 0.0 | 0 | 0.00 | 0 | 0.0 | 0 | 0.0 | 0 | 0 | 0 | 39.6 |
| T.J. Yates | Hou | 10 | 4 | 40.0 | 38 | 3.80 | 0 | 0.0 | 1 | 10.0 | 19 | 1 | 0 | 11.7 |
| Ryan Mallett | NE | 4 | 1 | 25.0 | 17 | 4.25 | 0 | 0.0 | 1 | 25.0 | 17 | 0 | 0 | 5.2 |
| Antonio Brown | Pit | 2 | 0 | 0.0 | 0 | 0.00 | 0 | 0.0 | 1 | 50.0 | 0 | 0 | 0 | 0.0 |
| Kendall Hunter | SF | 0 | 0 | 0.0 | 0 | 0.00 | 0 | 0.0 | 0 | 0.0 | 0 | 1 | 4 | 0.0 |
| Josh Johnson | Cle | 0 | 0 | 0.0 | 0 | 0.00 | 0 | 0.0 | 0 | 0.0 | 0 | 1 | 8 | 0.0 |
| Emmanuel Sanders | Pit | 0 | 0 | 0.0 | 0 | 0.00 | 0 | 0.0 | 0 | 0.0 | 0 | 1 | 7 | 0.0 |
| Brad Smith | Buf | 1 | 0 | 0.0 | 0 | 0.00 | 0 | 0.0 | 1 | 100.0 | 0 | 0 | 0 | 0.0 |
