| Interceptions | Tackles | Sacks | |||||||||
| Player | Team | Ints | Yds | Avg | Lg | TD | Solo | Ast | Tot | Sacks | Yds |
| Jerod Mayo | NE | 1 | 0 | 0.0 | 0 | 0 | 88 | 59 | 147 | 3.0 | 24.0 |
| Karlos Dansby | Mia | 0 | 0 | 0.0 | 0 | 0 | 101 | 33 | 134 | 1.0 | 9.0 |
| David Harris | NYJ | 0 | 0 | 0.0 | 0 | 0 | 79 | 44 | 123 | 3.0 | 15.5 |
| Nick Barnett | Buf | 0 | 0 | 0.0 | 0 | 0 | 72 | 40 | 112 | 2.0 | 3.0 |
| Kevin Burnett | Mia | 0 | 0 | 0.0 | 0 | 0 | 80 | 30 | 110 | 2.5 | 10.5 |
| George Wilson | Buf | 0 | 0 | 0.0 | 0 | 0 | 79 | 25 | 104 | 0.0 | 0.0 |
| LaRon Landry | NYJ | 2 | 42 | 21.0 | 24 | 1 | 76 | 24 | 100 | 0.0 | 0.0 |
| Chris Clemons | Mia | 2 | 29 | 14.5 | 29 | 0 | 72 | 26 | 98 | 0.0 | 0.0 |
| Reshad Jones | Mia | 4 | 28 | 7.0 | 15 | 0 | 73 | 21 | 94 | 1.0 | 5.0 |
| Brandon Spikes | NE | 0 | 0 | 0.0 | 0 | 0 | 57 | 35 | 92 | 1.0 | 2.0 |
| Yeremiah Bell | NYJ | 0 | 0 | 0.0 | 0 | 0 | 73 | 17 | 90 | 1.0 | 8.0 |
| Devin McCourty | NE | 5 | 53 | 10.6 | 34 | 0 | 63 | 19 | 82 | 0.0 | 0.0 |
| Kelvin Sheppard | Buf | 0 | 0 | 0.0 | 0 | 0 | 56 | 24 | 80 | 2.0 | 17.0 |
| Jairus Byrd | Buf | 5 | 81 | 16.2 | 45 | 0 | 53 | 23 | 76 | 0.0 | 0.0 |
| Kyle Arrington | NE | 0 | 0 | 0.0 | 0 | 0 | 62 | 12 | 74 | 0.0 | 0.0 |
| Muhammad Wilkerson | NYJ | 0 | 0 | 0.0 | 0 | 0 | 36 | 33 | 69 | 5.0 | 25.0 |
| Bryan Scott | Buf | 4 | 66 | 16.5 | 32 | 1 | 48 | 19 | 67 | 0.0 | 0.0 |
| Koa Misi | Mia | 0 | 0 | 0.0 | 0 | 0 | 50 | 15 | 65 | 3.5 | 15.5 |
| Stephon Gilmore | Buf | 1 | 23 | 23.0 | 23 | 0 | 52 | 9 | 61 | 0.0 | 0.0 |
| Dont'a Hightower | NE | 0 | 0 | 0.0 | 0 | 0 | 43 | 17 | 60 | 4.0 | 21.0 |
| Bart Scott | NYJ | 1 | 11 | 11.0 | 11 | 0 | 36 | 24 | 60 | 2.5 | 23.5 |
| Sean Smith | Mia | 2 | 31 | 15.5 | 31 | 0 | 53 | 6 | 59 | 0.0 | 0.0 |
| Rob Ninkovich | NE | 0 | 0 | 0.0 | 0 | 0 | 32 | 26 | 58 | 8.0 | 50.5 |
| Nigel Bradham | Buf | 0 | 0 | 0.0 | 0 | 0 | 37 | 20 | 57 | 0.0 | 0.0 |
| Calvin Pace | NYJ | 0 | 0 | 0.0 | 0 | 0 | 35 | 20 | 55 | 3.0 | 16.0 |
| Nolan Carroll | Mia | 0 | 0 | 0.0 | 0 | 0 | 46 | 7 | 53 | 1.0 | 5.0 |
| Cameron Wake | Mia | 0 | 0 | 0.0 | 0 | 0 | 38 | 15 | 53 | 15.0 | 92.0 |
| Mike DeVito | NYJ | 0 | 0 | 0.0 | 0 | 0 | 27 | 25 | 52 | 1.0 | 8.0 |
| Kyle Wilson | NYJ | 1 | 5 | 5.0 | 5 | 0 | 41 | 7 | 48 | 0.0 | 0.0 |
| Vince Wilfork | NE | 0 | 0 | 0.0 | 0 | 0 | 29 | 19 | 48 | 3.0 | 32.0 |
| Mario Williams | Buf | 0 | 0 | 0.0 | 0 | 0 | 37 | 9 | 46 | 10.5 | 51.0 |
| Kyle Williams | Buf | 0 | 0 | 0.0 | 0 | 0 | 27 | 19 | 46 | 5.0 | 29.0 |
| Chandler Jones | NE | 0 | 0 | 0.0 | 0 | 0 | 24 | 21 | 45 | 6.0 | 33.0 |
| Patrick Chung | NE | 2 | 27 | 13.5 | 27 | 0 | 29 | 15 | 44 | 0.0 | 0.0 |
| Jimmy Wilson | Mia | 0 | 0 | 0.0 | 0 | 0 | 36 | 5 | 41 | 2.0 | 14.0 |
| Tavon Wilson | NE | 4 | 87 | 21.8 | 45 | 0 | 28 | 13 | 41 | 0.0 | 0.0 |
| Ellis Lankster | NYJ | 2 | 0 | 0.0 | 0 | 0 | 33 | 6 | 39 | 1.0 | 2.0 |
| Marcell Dareus | Buf | 0 | 0 | 0.0 | 0 | 0 | 26 | 13 | 39 | 5.5 | 38.0 |
| Da'Norris Searcy | Buf | 0 | 0 | 0.0 | 0 | 0 | 26 | 13 | 39 | 0.0 | 0.0 |
| Justin Rogers | Buf | 1 | -1 | -1.0 | 0 | 0 | 32 | 5 | 37 | 0.0 | 0.0 |
| Steve Gregory | NE | 3 | 50 | 16.7 | 36 | 0 | 31 | 6 | 37 | 0.0 | 0.0 |
| Demario Davis | NYJ | 0 | 0 | 0.0 | 0 | 0 | 31 | 5 | 36 | 0.0 | 0.0 |
| Alfonzo Dennard | NE | 3 | 95 | 31.7 | 87t | 1 | 34 | 1 | 35 | 0.0 | 0.0 |
| Antonio Cromartie | NYJ | 3 | 53 | 17.7 | 40t | 1 | 30 | 5 | 35 | 0.0 | 0.0 |
| Jared Odrick | Mia | 0 | 0 | 0.0 | 0 | 0 | 26 | 9 | 35 | 5.0 | 29.0 |
| Garrett McIntyre | NYJ | 0 | 0 | 0.0 | 0 | 0 | 24 | 11 | 35 | 3.5 | 22.5 |
| Olivier Vernon | Mia | 0 | 0 | 0.0 | 0 | 0 | 25 | 7 | 32 | 3.5 | 21.0 |
| Aaron Williams | Buf | 0 | 0 | 0.0 | 0 | 0 | 24 | 8 | 32 | 0.0 | 0.0 |
| Quinton Coples | NYJ | 0 | 0 | 0.0 | 0 | 0 | 22 | 8 | 30 | 5.5 | 40.5 |
| Sione Pouha | NYJ | 0 | 0 | 0.0 | 0 | 0 | 20 | 9 | 29 | 1.0 | 2.0 |
