DG: Delay of Game, FS: False Start, HLD: Holding, OFF: Offsides, IC: Illegal Contact, PI: Pass Interference, RP: Roughing the Passer, PF: Personal Foul, UR: Unnecessary Roughness, UC: Unsportsmanlike Conduct
| Penalties | Penalty Breakdown | |||||||||||||
| Player | Pos | Team | Num | Yds | FS | HLD | OFF | IC | PI | RP | PF | UR | UC | Other |
| Giacomini, Breno | OT | Sea | 12 | 120 | 4 | 4 | 0 | 0 | 0 | 0 | 0 | 4 | 0 | 0 |
| Goldson, Dashon | DB | SF | 6 | 87 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 4 | 0 | 2 |
| Pollard, Bernard | DB | Bal | 5 | 71 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 3 | 0 | 1 |
| Reed, Ed | DB | Bal | 4 | 43 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 3 | 0 | 0 |
| Jackson, D'Qwell | LB | Cle | 3 | 45 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 3 | 0 | 0 |
| Boldin, Anquan | WR | Bal | 10 | 95 | 2 | 3 | 0 | 0 | 1 | 0 | 0 | 2 | 0 | 2 |
| Vaughn, Cassius | DB | Ind | 9 | 101 | 0 | 2 | 0 | 2 | 3 | 0 | 0 | 2 | 0 | 0 |
| Kelly, Tommy | DT | Oak | 9 | 75 | 0 | 0 | 2 | 0 | 0 | 1 | 0 | 2 | 0 | 4 |
| Smith, Aldon | DE | SF | 8 | 75 | 0 | 0 | 2 | 0 | 0 | 0 | 0 | 2 | 0 | 4 |
| Hall, DeAngelo | DB | Was | 7 | 77 | 0 | 2 | 0 | 0 | 0 | 0 | 0 | 2 | 0 | 3 |
| Griffin, Michael | DB | Ten | 6 | 80 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 2 | 0 | 2 |
| Davis, Anthony | OT | SF | 5 | 52 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 2 | 0 | 1 |
| Martin, Jonathan | OT | Mia | 5 | 40 | 2 | 0 | 0 | 0 | 0 | 0 | 0 | 2 | 0 | 1 |
| Lefeged, Joe | DB | Ind | 4 | 47 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 2 | 0 | 1 |
| Conte, Christopher | DB | Chi | 4 | 46 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 2 | 0 | 0 |
| Kalil, Matt | OT | Min | 4 | 40 | 2 | 0 | 0 | 0 | 0 | 0 | 0 | 2 | 0 | 0 |
| Moses, Dezman | LB | GB | 4 | 40 | 0 | 0 | 2 | 0 | 0 | 0 | 0 | 2 | 0 | 0 |
| Godfrey, Charles | DB | Car | 4 | 37 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 2 | 0 | 2 |
| Landry, Dawan | DB | Jac | 3 | 32 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 2 | 0 | 0 |
| Davis, Thomas | DB | Car | 3 | 22 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 2 | 0 | 0 |
| Dennard, Alfonzo | DB | NE | 3 | 21 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 2 | 0 | 0 |
| Tulloch, Stephen | LB | Det | 2 | 42 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 2 | 0 | 0 |
| Curry, Aaron | LB | Oak | 2 | 30 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 2 | 0 | 0 |
| Hunt, Phillip | LB | Phi | 2 | 30 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 2 | 0 | 0 |
| Rice, Ray | RB | Bal | 2 | 30 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 2 | 0 | 0 |
| Tapp, Darryl | DE | Phi | 2 | 30 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 2 | 0 | 0 |
| Cook, Chris | DB | Min | 2 | 27 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 2 | 0 | 0 |
| Loadholt, Phil | OT | Min | 11 | 85 | 5 | 2 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 3 |
| Carimi, Gabe | OT | Chi | 9 | 72 | 4 | 4 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
| Cherilus, Gosder | OT | Det | 9 | 67 | 5 | 2 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 1 |
| Fairley, Nick | DT | Det | 9 | 63 | 0 | 0 | 2 | 0 | 0 | 0 | 0 | 1 | 0 | 6 |
| Oher, Michael | OT | Bal | 8 | 75 | 3 | 3 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 1 |
| Mack, Alex | C | Cle | 8 | 60 | 3 | 3 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 1 |
| Cromartie, Antonio | DB | NYJ | 7 | 86 | 0 | 0 | 1 | 1 | 3 | 0 | 0 | 1 | 0 | 1 |
| Jefferson, A.J. | DB | Min | 7 | 66 | 0 | 2 | 0 | 1 | 3 | 0 | 0 | 1 | 0 | 0 |
| Hardy, Greg | DE | Car | 7 | 59 | 0 | 0 | 2 | 0 | 0 | 2 | 0 | 1 | 0 | 2 |
| Rachal, Chilo | OG | Chi | 7 | 59 | 3 | 3 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
| Long, Chris | DE | Stl | 7 | 55 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 1 | 0 | 4 |
| Harris, Brandon | DB | Hou | 7 | 48 | 0 | 2 | 0 | 1 | 2 | 0 | 0 | 1 | 0 | 1 |
| Bush, Jarrett | DB | GB | 7 | 45 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 3 |
| Culliver, Chris | DB | SF | 6 | 81 | 0 | 3 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 1 |
| Thomas, Josh | DB | Car | 6 | 66 | 1 | 1 | 0 | 0 | 2 | 0 | 0 | 1 | 0 | 1 |
| Stewart, David | OT | Ten | 6 | 65 | 1 | 3 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 1 |
| Spillman, C.J. | DB | SF | 6 | 61 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 4 |
| Smith, Lee | TE | Buf | 6 | 54 | 2 | 3 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
| Allen, Jared | DE | Min | 6 | 50 | 0 | 0 | 2 | 0 | 0 | 0 | 1 | 1 | 0 | 2 |
| Graham, Jimmy | TE | NO | 6 | 50 | 3 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 0 |
| Mebane, Brandon | DT | Sea | 6 | 50 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 5 |
| Wilfork, Vince | DT | NE | 6 | 49 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 4 |
| Bryant, Dez | WR | Dal | 6 | 45 | 1 | 2 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 2 |
