DG: Delay of Game, FS: False Start, HLD: Holding, OFF: Offsides, IC: Illegal Contact, PI: Pass Interference, RP: Roughing the Passer, PF: Personal Foul, UR: Unnecessary Roughness, UC: Unsportsmanlike Conduct
| Penalties | Penalty Breakdown | |||||||||||||
| Player | Pos | Team | Num | Yds | FS | HLD | OFF | IC | PI | RP | PF | UR | UC | Other |
| Rivers, Philip | QB | SD | 12 | 77 | 2 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 10 |
| Bradford, Sam | QB | Stl | 9 | 49 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 9 |
| Locker, Jake | QB | Ten | 7 | 44 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 7 |
| Wilson, Russell | QB | Sea | 7 | 42 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 7 |
| Romo, Tony | QB | Dal | 7 | 35 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 7 |
| Fairley, Nick | DT | Det | 9 | 63 | 0 | 0 | 2 | 0 | 0 | 0 | 0 | 1 | 0 | 6 |
| Brees, Drew | QB | NO | 6 | 69 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 5 |
| Mebane, Brandon | DT | Sea | 6 | 50 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 5 |
| Smith, Antonio | DE | Hou | 6 | 45 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 5 |
| Bennett, Michael | DE | TB | 6 | 40 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 5 |
| Freeman, Josh | QB | TB | 6 | 31 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 5 |
| Jenkins, Malcolm | DB | NO | 5 | 57 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 5 |
| Johnson, Charles | DE | Car | 5 | 37 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 5 |
| Kaepernick, Colin | QB | SF | 5 | 37 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 5 |
| Dalton, Andy | QB | Cin | 5 | 35 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 5 |
| Palmer, Carson | QB | Oak | 5 | 26 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 5 |
| Kelly, Tommy | DT | Oak | 9 | 75 | 0 | 0 | 2 | 0 | 0 | 1 | 0 | 2 | 0 | 4 |
| Smith, Aldon | DE | SF | 8 | 75 | 0 | 0 | 2 | 0 | 0 | 0 | 0 | 2 | 0 | 4 |
| Long, Chris | DE | Stl | 7 | 55 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 1 | 0 | 4 |
| Spillman, C.J. | DB | SF | 6 | 61 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 4 |
| Campbell, Tommie | DB | Ten | 6 | 56 | 0 | 2 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 4 |
| Wilfork, Vince | DT | NE | 6 | 49 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 4 |
| Marks, Sen'Derrick | DT | Ten | 6 | 44 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 4 |
| Smith, Torrey | WR | Bal | 6 | 42 | 2 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 4 |
| Williams, Kyle | DT | Buf | 6 | 32 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 4 |
| Griffin III, Robert | QB | Was | 5 | 43 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 4 |
| Manning, Eli | QB | NYG | 5 | 35 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 4 |
| Sheard, Jabaal | DE | Cle | 5 | 35 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 4 |
| Luck, Andrew | QB | Ind | 4 | 33 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 4 |
| Vickerson, Kevin | DT | Den | 4 | 30 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 4 |
| Newton, Cam | QB | Car | 4 | 28 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 4 |
| Cox, Fletcher | DT | Phi | 4 | 25 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 4 |
| Cassel, Matt | QB | KC | 4 | 23 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 4 |
| Rodgers, Aaron | QB | GB | 4 | 20 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 4 |
| Smith, Alex | QB | SF | 4 | 20 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 4 |
| Hasselbeck, Matt | QB | Ten | 4 | 17 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 4 |
| Loadholt, Phil | OT | Min | 11 | 85 | 5 | 2 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 3 |
| Miller, Von | LB | Den | 10 | 80 | 0 | 1 | 3 | 0 | 0 | 3 | 0 | 0 | 0 | 3 |
| Hall, DeAngelo | DB | Was | 7 | 77 | 0 | 2 | 0 | 0 | 0 | 0 | 0 | 2 | 0 | 3 |
| Bush, Jarrett | DB | GB | 7 | 45 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 3 |
| Hernandez, Aaron | TE | NE | 7 | 45 | 2 | 0 | 0 | 0 | 2 | 0 | 0 | 0 | 0 | 3 |
| Groves, Quentin | DE | Ari | 6 | 45 | 0 | 1 | 2 | 0 | 0 | 0 | 0 | 0 | 0 | 3 |
| Wilson, Martez | LB | NO | 6 | 44 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 3 |
| Washington, Daryl | LB | Ari | 5 | 54 | 0 | 0 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 3 |
| Stephenson, Donald | OG | KC | 5 | 48 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 3 |
| McLeod, Rodney | DB | Stl | 5 | 46 | 0 | 2 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 3 |
| Chancellor, Kam | DB | Sea | 5 | 25 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 3 |
| Pierre-Paul, Jason | DE | NYG | 5 | 24 | 0 | 0 | 2 | 0 | 0 | 0 | 0 | 0 | 0 | 3 |
| Dahl, Craig | DB | Stl | 4 | 33 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 3 |
| Liuget, Corey | DT | SD | 4 | 30 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 3 |
